| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| Greenville Hurricanes "A" | Clementine Fisher, Hattie Brown, Sadie Davis, Hannah Watson | 2:25.63 | ||
| Greer Middle College "A" | Maggie Patterson, Alice Lindblad, Charlotte Goad, Naomi Henning | 2:26.03 | ||
| Greenville Tech Charter "A" | Zoey Zimmerman, Ruby Archibald, Gracyn Schreel, Maddie Jones | 2:33.69 | ||
| Greenville Hurricanes "B" | Teagin Costanzo, Sophie Gustek, Caroline Medlin | 2:40.19 | ||
| Greer Middle College "B" | Aubrey Lindblad, Caroline Hasson, Brielle Williams | 2:57.94 | ||
| Oakbrook Preparatory School "A" | Estie Hice, Emma Hunt, Chloe Botchie, Emma Haas | 3:03.02 |