| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | West Ashley "A" | Sofia Savic, Cora Flanigan, Ashlyn Cook, Lila Perlmutter | 2:02.53 | |
| 2 | Fort Dorchester "A" | Avery Torek, Juliette Thibault, Kai Bergmann, Gabriella Burns | 2:09.81 | |
| 3 | West Ashley "B" | Clara Woolum, Gabriela Ross, Harper Hanna, Jane Robbins | 2:14.22 | |
| 4 | West Ashley "C" | Ana Savic, Gabriella Parks, Kaylee Berry, Julia Hodges | 2:29.32 |