| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Wando "A" | Sydney Boyette, Nadya Perron, Kamryn McCoy, Nora Fritts | 1:58.21 | 4 splits50: 28.88 (28.88) 100: 1:02.24 (33.36) 150: 1:32.23 (29.99) 200: 1:58.21 (25.98) |
| 2 | West Ashley "A" | Sofia Savic, Ashlyn Cook, Soleil Smith, Lila Perlmutter | 1:59.80 | 4 splits50: 32.07 (32.07) 100: 1:05.70 (33.63) 150: 1:34.61 (28.91) 200: 1:59.80 (25.19) |
| 3 | Wando "B" | Lily Loy, Doga Coskun, Hayden Frederick, Caroline Ferrera | 2:13.48 | 4 splits50: 32.50 (32.50) 100: 1:09.64 (37.14) 150: 1:44.19 (34.55) 200: 2:13.48 (29.29) |
| 4 | West Ashley "B" | Gabriella Parks, Mary Halford, Caroline Brown, Lillian Parks | 2:14.55 | 4 splits50: 34.86 (34.86) 100: 1:10.87 (36.01) 150: 1:45.41 (34.54) 200: 2:14.55 (29.14) |
| 5 | Wando "D" | Kaitlin Deeter, Charlotte Jablonski, AVA Daffron, Hannah Allin | 2:16.14 | 4 splits50: 34.10 (34.10) 100: 1:11.97 (37.87) 150: 1:48.15 (36.18) 200: 2:16.14 (27.99) |
| 6 | West Ashley "C" | Julia Hodges, Gabriela Ross, Emma Griggs, Elizabeth Klauber | 2:19.86 | 4 splits50: 38.39 (38.39) 100: 1:15.10 (36.71) 150: 1:48.39 (33.29) 200: 2:19.86 (31.47) |