| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Gray Collegiate Academy "A" | Whitney Moody, Madison Mitton, Sarah Coker, Peighton Johnson | 1:52.68 | |
| 2 | Aiken "A" | Elsa Horcher, Macy Harper, Greta Olson, Gabrielle Blaszczak | 1:53.62 | |
| 3 | Gray Collegiate Academy "B" | Addison Shellem, Jordyn Sanson, Charlotte Capece, Kennedy Harris | 2:08.89 | |
| 4 | Aiken "B" | Gina Hofstetter, Sarah Richardson, Gabrielle RIchardson, Adalin Grigsby | 2:14.45 | |
| 5 | North Augusta "A" | Karalyn Hammett, Zoe Emerling, Kennedy Cobb, Madison Steed | 2:15.79 | |
| 6 | South Aiken "A" | Sarah Tamburello, Addison Moss, Linda Colquitt, Briella O'Quinn | 2:22.35 | |
| 7 | South Aiken "B" | Kalila O'Quinn, Marian Mason, Sophia Bice, Rachel Mussetter | 2:33.02 | |
| 8 | North Augusta "B" | Ella Hutchins, Samantha Lafont, Natalie Bodkin, Nana Satoh | 2:34.86 | |
| 9 | Brookland-Cayce "A" | Heather Long, Zoe Bryan, Sarah Stikeleather, Eve Bryan | 2:35.01 | |
| 10 | Gilbert "A" | Jordan Humble, Emma Vanderpoel, Olivia Vanderpoel, Mollie Wilson | 2:56.54 |