| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Blythewood "A" | Scarlette Hankwitz, Catherine Maradei, Abigail Christian, Addison Maradei | 1:58.03 | |
| 1 | Mid-Carolina "A" | Miriam Eshaak, Baylee Willetts, Tailee Followell, Hannah Kubacz | 2:57.22 | |
| 2 | Blythewood "B" | Lily Kang, Ava Sanders, Nora Kang, Anya Hutchinson | 2:05.78 | |
| 2 | North Central "A" | Jema Boettinger, Samantha Vansant, Juliana Gallagher, Delia Rivera | 2:58.41 | |
| 3 | Lugoff-Elgin "A" | Layla Miller, Lydia Statham, Lydia Cyrier, Zoe Branham | 2:13.41 | |
| 4 | West Florence "A" | Evelyn Filyaw, Lauren Krawiec, Riley White, Dwyer Gude, Mia Holmes, Nancy Turner | 2:15.53 | |
| 5 | Blythewood "C" | Lauren Benson, Emily Pickens, Breana Cabrera, Sophia Gammons | 2:18.97 | |
| 6 | Lugoff-Elgin "B" | Rylee Watts, Presley Guster, Lyla Poe, Caitlyn Smith | 2:30.88 | |
| 7 | Spring Valley "B" | Greher Sexton, Evthokia Deligiannidis, Amie Merten, Lila Smith | 2:40.35 | |
| DQ | Spring Valley "A" | Camille Anderson, Jasmine Emokpae, Farrah Ballouli, Langley Aslin | — | |
| DQ | Sumter "A" | Avery Kirkhart, Oriana Perez, Kayla Langford, Riley Irick | — |