| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Socastee "A" | McKinen Solheim, Kyleigh Malena, Anisten Satterfield, Samantha Riley | 2:00.42 | |
| 2 | St James "A" | Ciena Farrell, Zlata Kulikovska, Jenna Guthinger, Zoe Puka | 2:02.45 | |
| 3 | Carolina Forest "A" | Kendall Hubbard, Gabriella Suarez, Kayleigh Hubbard, Macie Mosley | 2:07.32 | |
| 4 | North Myrtle Beach "A" | Kaitlyn Jones, Sadie Olson, Sydney Carroll, Skyleigh Averitt | 2:08.94 | |
| 5 | Myrtle Beach "A" | Adelae Flint, Danna Contreras, Ansley Link, Sofia Contreras | 2:13.50 | |
| 6 | Socastee "B" | Madison Ellerbe, Breanna Thompson, Madison Malena, Ava Midkiff | 2:15.01 | |
| 7 | North Myrtle Beach "B" | Christiana Baeli, Kennadi Justis, Alissa Lang, Lainee Smith | 2:27.94 | |
| 8 | Waccamaw "A" | Lillian Kunes, Georgia Madigan, Grace Ratliffe, Ellington Steel | 2:30.38 | |
| 9 | Socastee "C" | Natalia Nierwinski, Madelyn Cusati, Kaitlyn Mandel, Alexis Ellerbe | 2:31.75 | |
| 10 | St James "B" | Eliza Ackerman, Ashanty Gonzalez, Payton Houk, Olivia Ackerman | 2:50.35 | |
| DQ | Carolina Forest "B" | Carly Silva, Lillie Herlevi, Margaret Aycock, Maricely Sanchez Perez | — |