| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Eastside "B" | Ana Ballinger, Leila Kluttz, Lauren York, Darcy O'Sullivan | 1:56.39 | 4 splits50: 30.38 (30.38) 100: 1:03.69 (33.31) 150: 1:30.92 (27.23) 200: 1:56.39 (25.47) |
| 2 | Eastside "A" | Harper Penny, Anna Barr, Laila Harvey, Emma Jones | 1:58.12 | 4 splits50: 30.16 (30.16) 100: 1:03.18 (33.02) 150: 1:31.19 (28.01) 200: 1:58.12 (26.93) |
| 3 | Wade Hampton "A" | Lillian Maurer, Chelsea Girardeau, Abby Schneider, Lindsey Guertin | 1:58.69 | 1 splits200: 1:58.69 (1:58.69) |
| 4 | Eastside "C" | Marion Bolt, Anneliese Thaanum-Dean, Allison Moore, Adelaide Hankins | 2:02.11 | 4 splits50: 31.67 (31.67) 100: 1:06.48 (34.81) 150: 1:35.21 (28.73) 200: 2:02.11 (26.90) |
| 5 | Travelers Rest "A" | Isabella Brock, Lillie Prescott, Jayna Laven, Annabelle Taylor | 2:17.86 | 4 splits50: 31.82 (31.82) 100: 1:10.93 (39.11) 150: 1:51.03 (40.10) 200: 2:17.86 (26.83) |
| 6 | Wade Hampton "B" | Caroline Clarkson, Adrienne Nelson, Eleanor Lee, Ollie Tucker | 2:21.83 | 4 splits50: 35.99 (35.99) 100: 1:26.03 (50.04) 150: 1:53.93 (27.90) 200: 2:21.83 (27.90) |
| NS | Wade Hampton "C" | Katherine Williams, Angelena Chastain, Pearce Odum, Lillian Threatt | — |