| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | West Florence "A" | Nancy Turner, Olivia Owens, Riley White, Lauren Krawiec, Dwyer Gude, Evelyn Filyaw, Mia Holmes | 2:12.74 | |
| 2 | Governor's School "A" | Maddie Smith, Gracyn Ross, Jane Salter, Asha Kaikini | 2:17.71 | |
| 3 | South Florence "A" | Daija Torian, Caroline McInville, Deava Duvall, Anna Maxwell | 2:29.12 | |
| 4 | Governor's School "B" | Tanishka Agarwal, Reid Covington, Madi Bigham, Ellison Foster | 2:33.41 | |
| 5 | Wilson "A" | Diya Bharadwaj, Puja Bharadwaj, Eden Weinmann, Rani Gopal, Sierra Estridge, Morgan Krawiec | 2:46.63 | |
| 6 | Sumter "A" | Avery Kirkhart, Oriana Perez, Kayla Langford, Riley Irick | 2:46.79 | |
| 7 | Aynor "A" | Kensley Staples, McKay Beaver, Teagan Gierstorf, Brylee Wirt | 2:49.15 |