| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | St. Joseph's Catholic School "A" | Isabella Stewart, Odette Brown, Sutton Alexander, Rachel Overton | 2:15.68 | |
| 2 | St. Joseph's Catholic School "B" | Annette Plyler, Lily Welch, Riley Reed, Hailey Shiner | 2:26.20 | |
| 3 | Fountain Inn "A" | Elleanor Mouton, Reagan Boehm, Blakelee Sandifer, Sasha Flaig | 2:42.22 |