| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Beaufort "A" | AMORETTE CHAPMAN, MICHALLE RICKS, ELIZABETH JONES, LYDIA FRANCE | 2:13.94 | |
| 2 | May River "A" | Christina Gluck, Kaila Joyce, Janelle Trett, Evie Clayton | 2:15.49 | |
| 3 | Charleston Charter for Math and Science "A" | Christina Leshko, Maddie Fletcher, Lilyanna Cates, Kiersten Cannon | 2:27.04 |