| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Ashley Hall "A" | Ella Sidebottom, Amelia DeWolf, Amelia Lennon, Margaret Sidebottom | 2:08.19 | |
| 2 | Spartanburg Day "A" | Charlotte Roark, Chloe Hujik, Essence Olley, Mary Gilman | 2:16.59 | |
| 3 | Spartanburg Christian Academy "A" | Ellena Clark, Josi Meeks, Aubrey Mumma, Olivia Chappelear | 2:19.63 | |
| 4 | Ashley Hall "B" | London Edwards, Olivia Gaines, Madeleine Kopf, Kate Lennon | 2:23.09 | |
| 5 | Spartanburg Day "B" | Tessa Conrad, Madeleine Belmont, Keani Johnson, Meredith Garrett | 2:23.50 | |
| 6 | Oakbrook Preparatory School "A" | Rachel Lloyd, Emma Hunt, Chloe Botchie, Emma Haas | 2:34.72 | |
| 7 | First Presbyterian Academy "A" | Megan Ford, Payton Falcone, Avery Urness, Kyla Urness | 2:42.13 | |
| 8 | Spartanburg Day "C" | Elizabeth Barnes, Libby Evers, Eloise Frias, Lena Fox | 2:54.19 |