| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Aiken "A" | Elsa Horcher, Macy Harper, Greta Olson, Gabrielle Blaszczak | 2:02.19 | |
| 1 | Trinity Collegiate School "A" | Lila Hieshetter, Giselle Hieshetter, Danielle Moeckel, Paige Paison | 2:20.54 | |
| 2 | Aiken "B" | Adalin Grigsby, Sarah Richardson, Gina Hofstetter, Gabrielle RIchardson | 2:18.78 | |
| 2 | Wilson Hall "A" | Paige Sanders, Maria Angela Agno, Cat Bowman, Mary Ellen Thorne | 2:45.63 | |
| 3 | North Augusta "A" | Karalyn Hammett, Zoe Emerling, Kennedy Cobb, Madison Steed | 2:19.75 | |
| 3 | Heathwood Hall "A" | Greyson Kathrein, Charlotte Garvey, Alice Ballou, Danielle Grossman | 2:59.91 | |
| 4 | Strom Thurmond "A" | Lucinda Whatley, Sara Willis, Olivia Stevens, Isabella Boswell | 2:54.27 |