LE vs AC Flora, Irmo, RV, Cam, NC
| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | AC Flora "A" | Campbell Witte, Lynn Leaphart, Helyn Rieger, Sophia Decker | 2:06.19 | |
| 2 | Lugoff-Elgin "A" | Layla Miller, Lydia Statham, Lydia Cyrier, Zoe Branham | 2:14.88 | |
| 3 | AC Flora "B" | Hayden Hall, Cecilia Haas, Amelia Juran, Elisabeth Haught | 2:17.28 | |
| 4 | Irmo "A" | RAWSON BRABHAM, Savannah Forrest, Molly Nix, Addison Courtney | 2:22.72 | |
| 5 | Lugoff-Elgin "B" | Annabelle Silva, Layla Farmer, Lyla Poe, Caitlyn Smith | 2:27.10 | |
| 6 | Camden "A" | Millicent Kimpton, Isabella Najar, Eavan Johnson, Laine Redfearn | 2:27.81 | |
| 7 | AC Flora "C" | Madison Butler, Hayden Voyles, Delaney Good, Mary Kvam | 2:36.03 | |
| 8 | AC Flora "D" | Cam McQueen, Margaret Rawl, Elizabeth Goodwyn, Elizabeth Mancini | 2:38.82 | |
| 9 | Lugoff-Elgin "C" | Rylee Watts, Niki Snyder, Lilly Kelley, Viviana McNamee | 2:51.56 | |
| DQ | North Central "A" | Delia Rivera, Samantha Vansant, Jema Boettinger, Juliana Gallagher | — |