| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Aiken "A" | Elsa Horcher, Macy Harper, Greta Olson, Gina Hofstetter | 1:59.55 | |
| 2 | South Aiken "A" | Ella Heath, Rose Etheridge, Adelyn Parker, Jane Parrott | 2:08.66 | |
| 3 | Aiken "B" | Gabrielle Blaszczak, Sarah Richardson, Gabrielle RIchardson, Adalin Grigsby | 2:14.56 | |
| 4 | South Aiken "B" | Briella O'Quinn, Katherine Dalbec, Kalila O'Quinn, Marian Mason | 2:24.84 | |
| 5 | South Aiken "C" | Addison Moss, Sarah Tamburello, Linda Colquitt, Olivia Ascherman | 2:32.21 | |
| DQ | South Aiken "D" | Lexie Whitman, Cheyanne Knott, Sophia Bice, Trinity Farkas | — |