| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| J. L. Mann "A" | Claire Burns, Anna Gates Niles, Mary Brannon | 2:11.74 | ||
| J. L. Mann "B" | Lauren Armaly, Anna Clare Faulkner, Savannah Alexander, Emmy Leonard | 2:17.41 | ||
| Fountain Inn "A" | Maarijka Ashworth, Marie O'Such, Cadence Flaig, Cadence Zbin | 2:18.72 | ||
| Southside Christian School "A" | Brooklyn Tomkow, Grace Hunt, Caroline Burns, Amaya Kuge | 2:22.21 | ||
| Greenville Tech Charter "A" | Zoey Zimmerman, Piper Schreel, Gracyn Schreel, Ruby Archibald | 2:33.88 | ||
| Fountain Inn "B" | Elleanor Mouton, Reagan Boehm, Blakelee Sandifer, Sasha Flaig | 2:44.26 | ||
| Southside Christian School "B" | Milla Petrova, Ainsley Dix, Leia Sfiris, Naomi Buffaloe | 2:47.72 | ||
| Greenville Tech Charter "B" | June Gibbs, Ellie Buckingham, Kate Walsh, Maddie Jones | 2:51.64 |