| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | St. Joseph's Catholic School "A" | Catherine Lynn, Scarlett Ziegenfus, Sutton Alexander, Addison Wireman | 2:16.06 | |
| 2 | St. Joseph's Catholic School "B" | Claire Do, Maeve Alvis, Magnolia McClaran, Hailey Shiner | 2:24.72 | |
| 3 | Greenville Hurricanes "A" | Clementine Fisher, Hattie Brown, Sadie Davis, Hannah Watson | 2:28.37 | |
| 4 | Greenville Tech Charter "A" | Zoey Zimmerman, Piper Schreel, Gracyn Schreel, Ruby Archibald | 2:28.58 | |
| 5 | Powdersville "A" | Adiya Kapcoe, Brooke Wilder, Cara Tollison, Aliyah Butler | 2:29.34 | |
| 6 | Greenville Hurricanes "B" | Elyse Crabtree, Lucy Osborn, Sophie Gustek, Selah Towner | 2:40.31 | |
| 7 | Powdersville "B" | Everlee Lugo, Paige Ulrey, Aubrey Dill, Sofia Ananyan | 2:57.64 |