| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Wade Hampton "A" | Abby Schneider, Chelsea Girardeau, Lillian Maurer, Emily Schneider | 1:59.00 | |
| 2 | Byrnes "A" | Nyah Henderson, Addison Bowen, Bailey Williamson, Kira Garrett | 2:10.28 | |
| 3 | Greenville Tech Charter "A" | Gracyn Schreel, Piper Schreel, Kinley Rzepka, Ellie Buckingham | 2:13.81 | |
| 4 | Byrnes "B" | Kaleigh West, Caroline McCarty, Claire Schaub, Sophia Dobbins | 2:19.06 | |
| 5 | Greenville Tech Charter "B" | Zoey Zimmerman, Ruby Archibald, Kate Walsh, Shiloh Johnson | 2:27.59 | |
| 6 | Byrnes "C" | Ava Seman, Calla Garrett, Hope Slemenda, Amelia Hepfner | 2:41.78 |