| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Byrnes "A" | Izabella Strawn, Addison Bowen, Savannah Luttrell, Reese Seman | 2:00.94 | |
| 2 | Spartanburg "A" | Claire Lauer, Kathryn Freeman, Anna Elliott, Katie Davis | 2:01.87 | |
| 3 | Fountain Inn "A" | Haylie Gray, Cadence Flaig, Cadence Zbin, Maarijka Ashworth | 2:11.52 | |
| 4 | Spartanburg "B" | Harriet Lynch, Charlie Kimsey, Eliza Martin, Kennedy Bozard | 2:14.50 | |
| 5 | Byrnes "B" | Amelia Clarke, Elizabeth Brooks, Claire Schaub, Bailey Williamson | 2:17.91 | |
| 6 | Spartanburg "D" | Sofia Rubio, Charlotte Smith, Emma Greene, Mallori McCoy | 2:23.29 | |
| 7 | Spartanburg "C" | Colleen Gallagher, Elaina Martin, Anna Vidrine, Olivia Battocchio | 2:29.09 | |
| 8 | Byrnes "C" | Kaleigh West, Mackenzi Ogborn, Hope Slemenda, Ava Seman | 2:33.84 |