| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | West Ashley "A" | Sofia Savic, Jane Robbins, Soleil Smith, Isabella Luciano | 2:07.42 | |
| 2 | Porter-Gaud "A" | Zuri Swain, Sloan Pittard, Lilah Kowalski, Caitlin Baden | 2:11.39 | |
| 3 | West Ashley "B" | Clara Woolum, Gabriela Ross, Harper Hanna, Emma Griggs | 2:15.51 | |
| 4 | West Ashley "C" | Ana Savic, Ella Lathan, Tallulah Branton, Elizabeth Klauber | 2:26.73 | |
| 5 | Porter-Gaud "B" | Molly Doherty, Ann McIntosh, Lizzie Meden, Finola Donahue | 2:35.20 |