| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Spring Valley "A" | Camille Anderson, Jasmine Emokpae, Farrah Ballouli, Isabella Oliveira | 2:03.84 | |
| 2 | Dreher "A" | Mira Wachtel, Zara Shah-Fuente, Hazle Ligon, Annabelle Kip | 2:22.07 | |
| 3 | Lugoff-Elgin "A" | Annabelle Silva, Layla Farmer, Lyla Poe, Presley Guster | 2:25.28 | |
| 4 | Camden "A" | Gina Millington, Laine Redfearn, Eavan Johnson, Millicent Kimpton | 2:31.35 | |
| 5 | Spring Valley "B" | Amie Merten, Evthokia Deligiannidis, Annabelle Marrin, Ellery Spratt | 2:39.30 | |
| 6 | Lugoff-Elgin "B" | Rylee Watts, Niki Snyder, Lilly Kelley, Sadie Silva | 2:45.91 | |
| 7 | Camden "B" | Promise Groff, Isabella Najar, Zoe Merideth, Leia Branham | 2:46.49 | |
| 8 | North Central "A" | Jema Boettinger, Samantha Vansant, Juliana Gallagher, Delia Rivera | 2:59.59 |