| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Spartanburg "A" | Claire Lauer, Ellie Fisher, Anna Elliott, Katelyn Nunez | 2:04.73 | 4 splits50: 31.62 (31.62) 100: 1:08.41 (36.79) 150: 1:38.18 (29.77) 200: 2:04.73 (26.55) |
| 2 | Spartanburg "B" | Harriet Lynch, Amelia Phillips, Kathryn Freeman, Colleen Gallagher | 2:12.53 | 4 splits50: 33.85 (33.85) 100: 1:12.22 (38.37) 150: 1:46.40 (34.18) 200: 2:12.53 (26.13) |
| 3 | Spartanburg "C" | Elaina Martin, Charlotte Smith, Charlie Kimsey, Kennedy Bozard | 2:23.85 | 4 splits50: 41.41 (41.41) 100: 1:21.55 (40.14) 150: 1:57.78 (36.23) 200: 2:23.85 (26.07) |
| 4 | Byrnes "B" | Sophia Dobbins, Mackenzi Ogborn, Kaleigh West, Amelia Clarke | 2:27.62 | 4 splits50: 36.11 (36.11) 100: 1:19.63 (43.52) 150: 1:55.75 (36.12) 200: 2:27.62 (31.87) |
| 5 | Spartanburg "D" | Sofia Rubio, Faye Krick-Aigner, Emma Greene, Seher Islam | 2:30.69 | 4 splits50: 37.99 (37.99) 100: 1:21.59 (43.60) 150: 2:00.69 (39.10) 200: 2:30.69 (30.00) |
| 6 | Byrnes "C" | Amelia Hepfner, Calla Garrett, Hope Slemenda, Katherine Schaub | 2:51.84 | 3 splits50: 50.22 (50.22) 150: 2:19.86 (1:29.64) 200: 2:51.84 (31.98) |
| DQ | Byrnes "A" | Addison Bowen, Elizabeth Brooks, Bailey Williamson, Caroline McCarty | — | 4 splits50: 30.60 (30.60) 100: 1:09.06 (38.46) 150: 1:42.93 (33.87) 200: 2:09.77 (26.84) |