FOM vs. NFD vs. NOW vs. YRK vs. RWA
| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | Fort Mill "A" | Haruka Ono, Lila Hadley, Isabella Corbi, MacKenzie Spurrier | 1:51.00 | |
| 2 | Nation Ford "A" | Kenna Zimmerly, Abigail Garcia, Costner Kolatis, Brittany Fink | 1:51.47 | |
| 3 | Fort Mill "B" | Caylin Charnas, Delaney Michael, Emma Michael, Isabella Sorenson | 1:57.43 | |
| 4 | Fort Mill "C" | Agne Zilinskaite, Hayden Fay, Gwen Tanis, Claire Olson | 1:59.97 | |
| 5 | Nation Ford "B" | Armenthia Barrera, Madeline Gladfelter, Elise Hay, Gabrielle Costa | 2:04.14 | |
| 6 | Nation Ford "C" | Elliot Petrus, Kennedy DeWaele, Giulianna Tuarez, Annaliese Coleman | 2:08.01 | |
| 7 | Fort Mill "D" | Elin Culver, Abigail Baird, Elise Netherton, Kaitlin Block | 2:08.02 | |
| 8 | Northwestern "A" | Hannah Johnson, Brooke Schake, Hannah Andrychowski, Charlie Wallace | 2:12.45 | |
| 9 | York Comprehensive "A" | Ava Haese, Kayla Thomson, Adelynn Branch, Caroline Mitchell | 2:15.06 | |
| 10 | Northwestern "B" | Eva Moore, Eliana Dugger, Kyleigh McCoy, Rawley Biddix | 2:30.26 | |
| DQ | York Comprehensive "B" | Taylen Zelakowski, Arsher Balarao, Mollie Hanks, Mirland Munoz | — |