| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| St. Joseph's Catholic School "A" | Odette Brown, Riley Reed, Rachel Overton | 2:14.52 | ||
| Daniel "A" | Sophia Harrer, Mary Greene, Elizabeth Russell, Bailey Choi | 2:16.64 | ||
| St. Joseph's Catholic School "B" | Catherine Lynn, Scarlett Ziegenfus, Claire Do, Addison Wireman | 2:20.70 | ||
| Greer Middle College "A" | Maggie Patterson, Alice Lindblad, Charlotte Goad, Naomi Henning | 2:28.06 | ||
| Daniel "B" | Melanie McKinnon, Jocelyn Campbell, Sophie Ayers, Glory Marshall | 2:43.88 | ||
| Greer Middle College "B" | Aubrey Lindblad, Nora Edwards, Caroline Hasson | 2:46.96 |