| Place | Team | Swimmers | Time | Splits |
|---|---|---|---|---|
| 1 | West Ashley "A" | Sofia Savic, Ashlyn Cook, Soleil Smith, Lila Perlmutter | 2:00.35 | |
| 2 | Oceanside Collegiate Academy "A" | Ella Johnson, Lily Holland, Caitlin Triplett, Eryn Lee | 2:02.41 | |
| 3 | Academic Magnet "A" | Charlotte Connors, Priya Cardella, Elena Barber, Julia Koch | 2:07.44 | |
| 4 | Oceanside Collegiate Academy "B" | Dakota Reilly, Camila Causey, Kate Baldwin, Elizabeth Littleton | 2:10.06 | |
| 5 | West Ashley "B" | Clara Woolum, Mary Halford, Harper Hanna, Isabella Luciano | 2:13.15 | |
| 6 | Academic Magnet "B" | Sarah Heinemann, Ruth Russell, Moxie-Jo Galvin, Charlee Bonavita | 2:15.91 | |
| 7 | West Ashley "C" | Gabriella Parks, Gabriela Ross, Emma Griggs, Caroline Brown | 2:15.94 | |
| DQ | Academic Magnet "C" | Finley Bowers, Katherine Childers, Bowen Arnold, Tiffani Tatzel | — |